exRNAdisease

Entry Detail

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General Information

Database ID: exR0762074 RNA Name: PLCG2 RNA Type: mRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 81739097 End Site(bp): 81962685 External Links: ENSG00000197943

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE106804 Description: Engineered Nanointerfaces for Microfluidic Isolation and Molecular Profiling of Tumor-specific Extracellular Vesicles Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 13 Number of Control: 6 Number of Samples: 19

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC000093.1 chr22 19717220 19724772 + AC005943.1 chr19 1578339 1605445 - AC009133.6 chr16 29812261 29820092 + AC091167.2 chr15 90249556 90272208 + AC137834.1 chr12 57249609 57296484 - AC138811.2 chr16 18788063 18801519 - AC245033.1 chr15 82536788 82573194 - ACTB chr7 5527148 5563784 - ADCY9 chr16 3953387 4116442 - AGO1 chr1 35869808 35930532 + AHCY chr20 34280268 34311802 - AKAP1 chr17 57085092 57121346 + AL365205.1 chr6 41780349 41790141 + ALDH1A2 chr15 57953424 58497866 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-6506-3p chr16 15611031 15611052 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC067930.1 chr8 143579636 143580670 + AC067930.4 chr8 143573490 143577397 + AC091564.7 chr11 6610883 6616594 - AC099524.1 chr16 81738248 81767868 + AC109460.3 chr16 28974804 28990775 + AD000090.1 chr19 35557956 35581954 + AL096870.2 chr14 24209646 24215987 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 29330365 Title: Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Author: Re¨¢tegui E, van der Vos KE, Lai CP, Zeinali M, Atai NA, Aldikacti B, Floyd FP Jr, H Khankhel A, Thapar V, Hochberg FH, Sequist LV, Nahed BV, S Carter B, Toner M, Balaj L, T Ting D, Breakefield XO, Stott SL. Journal: Nat Commun. 2018 Jan 12;9(1):175. Description: Tumor-derived EVs have the potential to be utilized as disease-specific biomarkers, and genes specific to GBM as well as transcripts that are hallmarks for the four genetic subtypes of the disease.