| Experiment ID | EXP00015 |
| Reference | Title: A microRNA polycistron as a potential human oncogene. Author: He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S,Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM. Journal: Nature. 2005 Jun 9;435(7043):828-33. Abstract: To date, more than 200 microRNAs have been described in humans; however, theprecise functions of these regulatory, non-coding RNAs remains largely obscure.One cluster of microRNAs, the mir-17-92 polycistron, is located in a region ofDNA that is amplified in human B-cell lymphomas. Here we compared B-cell lymphomasamples and cell lines to normal tissues, and found that the levels of theprimary or mature microRNAs derived from the mir-17-92 locus are oftensubstantially increased in these cancers. Enforced expression of the mir-17-92cluster acted with c-myc expression to accelerate tumour development in a mouseB-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir-17-92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together,these studies indicate that non-coding RNAs, specifically microRNAs, can modulatetumour formation, and implicate the mir-17-92 cluster as a potential humanoncogene. PMID: 15944707 |
| Expressiion Profile | Description: MicroRNA expression in lymphoma lines Organism: Homo sapiens GEO ID: GSE2399 Platform: GPL1899 Number of samples: 40 |
| Design and Sample | Cancer Type: lymphoma Cancer SubType: Gastric lymphoma Cell Line: Manca Experimental Design: subtype1 vs substype2 Case Sample: Manca Control Sample: OCI-Ly4 Num of Case: 4 Num of Control: 4 Quantification Software: Limma Num of miRNAs: 190 |
| Identification | Num of Up: 7 Num of Down: 13 |