| Experiment ID | EXP00030 |
| Reference | Title: A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas. Author: Wang T, Zhang X, Obijuru L, Laser J, Aris V, Lee P, Mittal K, Soteropoulos P, Wei JJ. Journal: Genes Chromosomes Cancer. 2007 Apr;46(4):336-47. Abstract: Human uterine leiomyomas (ULMs) are the most common neoplasms of women. Manygenes are dysregulated in ULMs and some of this dysregulation may be due toabnormal expression of micro-RNAs (miRNAs). In this study, 55 ULMs and matchedmyometrium were collected from 41 patients for microarray-based global miRNAexpression analysis. Of 206 miRNAs examined, 45 miRNAs were significantly up- or down-regulated in ULMs in comparison to the matched myometrium (P < 0.001). Thetop five dysregulated miRNAs in ULMs are the let-7 family, miR-21, miR-23b,miR-29b, and miR-197. Four polycistronic clusters of miRNAs were either up- ordown-regulated, but not in a mixed pattern, indicative of coordinated regulation of these miRNAs. Significance analysis revealed that subsets of miRNAs werestrongly associated with tumor sizes and race. By prediction analysis weidentified some important tumorigenic genes previously identified in ULMs thatmay be targeted by the dysregulated miRNAs. HMGA2 was identified as one of targetgenes of the let-7 family of miRNAs and has been found to be suppressed by let-7 in vitro. This article contains Supplementary material available athttp://www.interscience.wiley.com/jpages/1045-2257/suppmat. PMID: 17243163 |
| Expressiion Profile | Description: Human Uterine Leiomyomata microRNA gene expression Organism: Homo sapiens GEO ID: GSE5244 Platform: GPL3879 Number of samples: 51 |
| Design and Sample | Cancer Type: uterus cancer Cancer SubType: N/D Cell Line: N/D Experimental Design: cancer vs normal Case Sample: Uterine Leiomyomata Control Sample: myometrium tissue Num of Case: 51 Num of Control: 51 Quantification Software: LImma Num of miRNAs: 206 |
| Identification | Num of Up: 42 Num of Down: 106 |