| Experiment ID | EXP00031 |
| Reference | Title: Distinctive microRNA profiles relating to patient survival in esophageal squamouscell carcinoma. Author: Guo Y, Chen Z, Zhang L, Zhou F, Shi S, Feng X, Li B, Meng X, Ma X, Luo M, ShaoK, Li N, Qiu B, Mitchelson K, Cheng J, He J. Journal: Cancer Res. 2008 Jan 1;68(1):26-33. doi: 10.1158/0008-5472.CAN-06-4418. Abstract: Esophageal cancer is the sixth leading cause of death from cancer and one of the least studied cancers worldwide. The global microRNA expression profile ofesophageal cancer has not been reported previously. Here, for the first time, we have investigated expressed microRNAs in cryopreserved esophageal cancer tissues using advanced microRNA microarray techniques. Our microarray analyses identifiedseven microRNAs that could distinguish malignant esophageal cancer lesions fromadjacent normal tissues. Some microRNAs could be correlated with the differentclinicopathologic classifications. High expression of hsa-miR-103/107 correlated with poor survival by univariate analysis as well as by multivariate analysis.These results indicate that microRNA expression profiles are important diagnosticand prognostic markers of esophageal cancer, which might be analyzed simply usingeconomical approaches such as reverse transcription-PCR. PMID: 18172293 |
| Expressiion Profile | Description: Distinctive microRNA profiles relating to patient survival in esophageal squamous cell carcinoma Organism: Homo sapiens GEO ID: GSE6188 Platform: GPL4508 Number of samples: 257 |
| Design and Sample | Cancer Type: esophageal cancer Cancer SubType: N/D Cell Line: N/D Experimental Design: cancer vs normal Case Sample: cancer tissue Control Sample: adjacent normal tissue Num of Case: 153 Num of Control: 104 Quantification Software: Limma Num of miRNAs: 294 |
| Identification | Num of Up: 91 Num of Down: 86 |