| Experiment ID | EXP00081 |
| Reference | Title: Identification of metastasis-related microRNAs in hepatocellular carcinoma. Author: Budhu A, Jia HL, Forgues M, Liu CG, Goldstein D, Lam A, Zanetti KA, Ye QH, QinLX, Croce CM, Tang ZY, Wang XW. Journal: Hepatology. 2008 Mar;47(3):897-907. doi: 10.1002/hep.22160. Abstract: MicroRNAs (miRNAs) have been used as cancer-related biomarkers. Hepatocellularcarcinoma (HCC) is an aggressive cancer with a dismal outcome largely due tometastasis and postsurgical recurrence. We investigated whether the expression ofcertain miRNAs are associated with HCC metastasis. We examined the miRNAexpression profiles of 482 cancerous and noncancerous specimens from radicalresection of 241 patients with HCC. Using a supervised algorithm and a clinicallywell-defined cohort of 131 cases, we built a unique 20-miRNA metastasis signaturethat could significantly predict (P < 0.001) primary HCC tissues with venousmetastases from metastasis-free solitary tumors with 10-fold cross-validation.However, significant miRNAs could not be identified from the correspondingnoncancerous hepatic tissues. A survival risk prediction analysis revealed that amajority of the metastasis-related miRNAs were associated with survival.Furthermore, the 20-miRNA tumor signature was validated in 110 additional casesas a significant independent predictor of survival (P = 0.009) and wassignificantly associated with both survival and relapse in 89 cases of earlystage HCC (P = 0.022 and 0.002, respectively). These 20 miRNAs may provide asimple profiling method to assist in identifying patients with HCC who are likelyto develop metastases/recurrence. In addition, functional analysis of thesemiRNAs may enhance our biological understanding of HCC metastasis. PMID: 18176954 |
| Expressiion Profile | Description: Unique MicroRNA Expression Signature Predicts Survival, Metastases and Recurrence of HCC Organism: Homo sapiens GEO ID: GSE6857 Platform: GPL4700 Number of samples: 482 |
| Design and Sample | Cancer Type: hepatocellular carcinoma Cancer SubType: N/D Cell Line: N/D Experimental Design: cancer vs normal Case Sample: hepatocellular carcinoma Control Sample: normal liver Num of Case: 241 Num of Control: 241 Quantification Software: Limma Num of miRNAs: 225 |
| Identification | Num of Up: 66 Num of Down: 123 |