| Experiment ID | EXP00132 |
| Reference | Title: Nodal marginal zone lymphoma: gene expression and miRNA profiling identifydiagnostic markers and potential therapeutic targets. Author: Arribas AJ, Campos-Martín Y, Gómez-Abad C, Algara P, Sánchez-Beato M,Rodriguez-Pinilla MS, Montes-Moreno S, Martinez N, Alves-Ferreira J, Piris MA,Mollejo M. Journal: Blood. 2012 Jan 19;119(3):e9-e21. doi: 10.1182/blood-2011-02-339556. Epub 2011Nov 22. Abstract: Nodal marginal zone lymphoma (NMZL) is a small B-cell neoplasm whose molecularpathogenesis is still essentially unknown and whose differentiation from othersmall B-cell lymphomas is hampered by the lack of specific markers. We haveanalyzed gene expression, miRNA profile, and copy number data from 15 NMZL cases.For comparison, 16 follicular lymphomas (FLs), 9 extranodal marginal zonelymphomas, and 8 reactive lymph nodes and B-cell subtypes were included. Theresults were validated by quantitative RT-PCR in an independent series, including61 paraffin-embedded NMZLs. NMZL signature showed an enriched expression of gene sets identifying interleukins, integrins, CD40, PI3K, NF-κB, and TGF-β, andincluded genes expressed by normal marginal zone cells and memory B cells. Themost highly overexpressed genes were SYK, TACI, CD74, CD82, and CDC42EP5. Geneslinked to G(2)/M and germinal center were down-regulated. Comparison of the gene expression profiles of NMZL and FL showed enriched expression of CHIT1, TGFB1,and TACI in NMZL, and BCL6, LMO2, and CD10 in FL. NMZL displayed increasedexpression of miR-221, miR-223, and let-7f, whereas FL strongly expressedmiR-494. Our study identifies new candidate diagnostic molecules for NMZL andreveals survival pathways activated in NMZL. PMID: 22110251 |
| Expressiion Profile | Description: microRNA-expression profile in a series of Nodal marginal zone lymphoma patients [miRNA expression] Organism: Homo sapiens GEO ID: GSE32232 Platform: GPL9081 Number of samples: 46 |
| Design and Sample | Cancer Type: lymphoma Cancer SubType: B-cell non-Hodgkin lymphoma Cell Line: N/D Experimental Design: cancer vs normal Case Sample: B-cell non-Hodgkin lymphoma Control Sample: lymph nodes with reactive lymphoid hyperplasia Num of Case: 40 Num of Control: 6 Quantification Software: Limma Num of miRNAs: 462 |
| Identification | Num of Up: 3 Num of Down: 9 |