| Experiment ID | EXP00146 |
| Reference | Title: miR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma. Author: Tao ZH, Wan JL, Zeng LY, Xie L, Sun HC, Qin LX, Wang L, Zhou J, Ren ZG, Li YX,Fan J, Wu WZ. Journal: J Exp Med. 2013 Apr 8;210(4):789-803. doi: 10.1084/jem.20120153. Epub 2013 Mar11. Abstract: MicroRNAs (miRNAs) play a critical role in tumor metastasis. In this study, weidentified a set of 32 miRNAs involved in hepatocellular carcinoma (HCC)metastasis. Among them, miR-612 was shown for the first time to have inhibitoryeffects on HCC proliferation, migration, invasion, and metastasis. AKT2 wasverified to be one of the direct targets of miR-612, through which theepithelial-mesenchymal transition (EMT) and metastasis were inhibited. The level of miR-612 in HCC patients was inversely associated with tumor size, stage, EMT, and metastasis. Of particular importance, miR-612 is involved in both the initialand final steps of the metastatic cascade, by suppressing local invasion anddistant colonization. The pleiotropic roles of miR-612 in the HCC metastaticcascade suggest that it could be an effective target for both early and advanced HCC. PMID: 23478189 |
| Expressiion Profile | Description: Human hepatocellular carcinoma: primary tumor vs.lung metastasis Organism: Homo sapiens GEO ID: GSE26323 Platform: GPL11362 Number of samples: 6 |
| Design and Sample | Cancer Type: hepatocellular carcinoma Cancer SubType: N/D Cell Line: N/D Experimental Design: metastasis Case Sample: lung metastasis of HCC Control Sample: primary HCC Num of Case: 3 Num of Control: 3 Quantification Software: Limma Num of miRNAs: 852 |
| Identification | Num of Up: 93 Num of Down: 108 |