| Experiment ID | EXP00149 |
| Reference | Title: Polycomb-mediated loss of miR-31 activates NIK-dependent NF-κB pathway in adult Tcell leukemia and other cancers. Author: Yamagishi M, Nakano K, Miyake A, Yamochi T, Kagami Y, Tsutsumi A, Matsuda Y,Sato-Otsubo A, Muto S, Utsunomiya A, Yamaguchi K, Uchimaru K, Ogawa S, WatanabeT. Journal: Cancer Cell. 2012 Jan 17;21(1):121-35. doi: 10.1016/j.ccr.2011.12.015. Abstract: Constitutive NF-κB activation has causative roles in adult T cell leukemia (ATL) caused by HTLV-1 and other cancers. Here, we report a pathway involvingPolycomb-mediated miRNA silencing and NF-κB activation. We determine the miRNAsignatures and reveal miR-31 loss in primary ATL cells. MiR-31 negativelyregulates the noncanonical NF-κB pathway by targeting NF-κB inducing kinase(NIK). Loss of miR-31 therefore triggers oncogenic signaling. In ATL cells,miR-31 level is epigenetically regulated, and aberrant upregulation of Polycombproteins contribute to miR-31 downregulation in an epigenetic fashion, leading toactivation of NF-κB and apoptosis resistance. Furthermore, this emerging circuit operates in other cancers and receptor-initiated NF-κB cascade. Our findingsprovide a perspective involving the epigenetic program, inflammatory responses,and oncogenic signaling. PMID: 22264793 |
| Expressiion Profile | Description: miRNA expression profiling in Adult T-cell Leukemia (ATL) cells and in Normal CD4+ T-cells Organism: Homo sapiens GEO ID: GSE31629 Platform: GPL7731 Number of samples: 62 |
| Design and Sample | Cancer Type: leukemia Cancer SubType: N/D Cell Line: N/D Experimental Design: cancer vs normal Case Sample: T-cell Leukemia Control Sample: Normal CD4+ T-cell Num of Case: 40 Num of Control: 22 Quantification Software: Limma Num of miRNAs: 719 |
| Identification | Num of Up: 52 Num of Down: 71 |