| Experiment ID | EXP00157 |
| Reference | Title: MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhancesβ-catenin signaling. Author: Zhang P, Bill K, Liu J, Young E, Peng T, Bolshakov S, Hoffman A, Song Y,Demicco EG, Terrada DL, Creighton CJ, Anderson ML, Lazar AJ, Calin GG, PollockRE, Lev D. Journal: Cancer Res. 2012 Apr 1;72(7):1751-62. doi: 10.1158/0008-5472.CAN-11-3027. Epub2012 Feb 20. Abstract: Liposarcoma can be an aggressive, debilitating, and fatal malignancy. In thisstudy, we identifed miRNAs associated with the differentiation status ofliposarcoma to gain insight into the basis for its progression. miRNA expression profiles determined in human tumors and normal fat specimens identified adedifferentiated tumor expression signature consisting of 35 miRNAs. Deregulated miRNA expression was confirmed in a second independent sample cohort. The miR-155was the most overexpressed miRNA and functional investigations assigned animportant role in the growth of dedifferentiated liposarcoma cell lines.Transient or stable knockdown of miR-155 retarded tumor cell growth, decreasedcolony formation, and induced G(1)-S cell-cycle arrest in vitro and blocked tumorgrowth in murine xenografts in vivo. We identified casein kinase 1α (CK1α) as adirect target of miR-155 control which enhanced β-catenin signaling and cyclin D1expression, promoting tumor cell growth. In summary, our results point toimportant functions for miR-155 and β-catenin signaling in progression ofliposarcoma, revealing mechanistic vulnerabilities that might be exploited forboth prognostic and therapeutic purposes. PMID: 22350414 |
| Expressiion Profile | Description: MicroRNAs differentially expressed in liposarcoma Organism: Homo sapiens GEO ID: GSE31045 Platform: GPL7723 Number of samples: 25 |
| Design and Sample | Cancer Type: sarcoma Cancer SubType: liposarcoma Cell Line: N/D Experimental Design: cancer vs normal Case Sample: liposarcoma Control Sample: normal fat Num of Case: 17 Num of Control: 8 Quantification Software: Limma Num of miRNAs: 835 |
| Identification | Num of Up: 72 Num of Down: 62 |