| Experiment ID | EXP00159 |
| Reference | Title: Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway. Author: Bueno MJ, Gómez de Cedrón M, Gómez-López G, Pérez de Castro I, Di Lisio L,Montes-Moreno S, Martínez N, Guerrero M, Sánchez-Martínez R, Santos J, Pisano DG,Piris MA, Fernández-Piqueras J, Malumbres M. Journal: Blood. 2011 Jun 9;117(23):6255-66. doi: 10.1182/blood-2010-10-315432. Epub 2011Apr 8. Abstract: Many mammalian transcripts contain target sites for multiple miRNAs, although it is not clear to what extent miRNAs may coordinately regulate single genes. Wehave mapped the interactions between down-regulated miRNAs and overexpressedtarget protein-coding genes in murine and human lymphomas. Myc, one of thehallmark oncogenes in these lymphomas, stands out as the up-regulated gene withthe highest number of genetic interactions with down-regulated miRNAs in mouselymphomas. The regulation of Myc by several of these miRNAs is confirmed bycellular and reporter assays. The same approach identifies MYC and multiple Myctargets as a preferential target of down-regulated miRNAs in human Burkittlymphoma, a pathology characterized by translocated MYC oncogenes. These results indicate that several miRNAs must be coordinately down-regulated to enhancecritical oncogenes, such as Myc. Some of these Myc-targeting miRNAs are repressedby Myc, suggesting that these tumors are a consequence of the unbalanced activityof Myc versus miRNAs. PMID: 21478429 |
| Expressiion Profile | Description: Combinatorial effects of microRNA to suppress the myc oncogenic pathway (miRNA data) Organism: Homo sapiens GEO ID: GSE29491 Platform: GPL8617 Number of samples: 26 |
| Design and Sample | Cancer Type: lymphoma Cancer SubType: B cell lymphoma Cell Line: N/D Experimental Design: cancer vs normal Case Sample: B cell lymphoma Control Sample: normal tissue Num of Case: 12 Num of Control: 14 Quantification Software: Limma Num of miRNAs: 468 |
| Identification | Num of Up: 38 Num of Down: 40 |