| Experiment ID | EXP00183 |
| Reference | Title: MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase2 in liver cancer. Author: Noh JH, Chang YG, Kim MG, Jung KH, Kim JK, Bae HJ, Eun JW, Shen Q, Kim SJ,Kwon SH, Park WS, Lee JY, Nam SW. Journal: Cancer Lett. 2013 Jul 28;335(2):455-62. doi: 10.1016/j.canlet.2013.03.003. Epub2013 Mar 14. Abstract: Aberrant regulation of histone deacetylase 2 (HDAC2) plays a pivotal role in the development of hepatocellular carcinoma (HCC), but, the underlying mechanismleading to HDAC2 overexpression is not well understood. We performed microRNA(miRNA) profiling analysis in a subset of HCCs, and identified fourdown-regulated miRNAs that may target HDAC2 in HCC. Ectopic expression of miRNAmimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells. Thistreatment repressed cancer cell growth and recapitulated HDAC2 knockdown effects on HCC cells. In conclusion, we suggest that loss or suppression of miR-145 maycause aberrant overexpression of HDAC2 and promote HCC tumorigenesis. PMID: 23499894 |
| Expressiion Profile | Description: Oncogenic Potential of SIRT7 in Human Hepatocellular Carcinoma and its Regulation by the Tumor Suppressors MiR-125a-5p and MiR-125b Organism: Homo sapiens GEO ID: GSE39678 Platform: GPL15852 Number of samples: 24 |
| Design and Sample | Cancer Type: hepatocellular carcinoma Cancer SubType: N/D Cell Line: N/D Experimental Design: cancer vs normal Case Sample: hepatocellular carcinoma Control Sample: normal liver Num of Case: 16 Num of Control: 8 Quantification Software: Limma Num of miRNAs: 399 |
| Identification | Num of Up: 55 Num of Down: 46 |