| Experiment ID | EXP00325 |
| Reference | Title: Toward the blood-borne miRNome of human diseases. Author: Keller A, Leidinger P, Bauer A, Elsharawy A, Haas J, Backes C, Wendschlag A,Giese N, Tjaden C, Ott K, Werner J, Hackert T, Ruprecht K, Huwer H, Huebers J,Jacobs G, Rosenstiel P, Dommisch H, Schaefer A, Müller-Quernheim J, Wullich B,Keck B, Graf N, Reichrath J, Vogel B, Nebel A, Jager SU, Staehler P, Amarantos I,Boisguerin V, Staehler C, Beier M, Scheffler M, Büchler MW, Wischhusen J,Haeusler SF, Dietl J, Hofmann S, Lenhof HP, Schreiber S, Katus HA, Rottbauer W,Meder B, Hoheisel JD, Franke A, Meese E. Journal: Nat Methods. 2011 Sep 4;8(10):841-3. doi: 10.1038/nmeth.1682. Abstract: In a multicenter study, we determined the expression profiles of 863 microRNAs byarray analysis of 454 blood samples from human individuals with different cancersor noncancer diseases, and validated this 'miRNome' by quantitative real-timePCR. We detected consistently deregulated profiles for all tested diseases;pathway analysis confirmed disease association of the respective microRNAs. Weobserved significant correlations (P = 0.004) between the genomic location ofdisease-associated genetic variants and deregulated microRNAs. PMID: 21892151 |
| Expressiion Profile | Description: The human Whole miRNOme project version 1 Organism: Homo sapiens GEO ID: GSE31568 Platform: GPL9040 Number of samples: 453 |
| Design and Sample | Cancer Type: ovarian cancer Cancer SubType: N/D Cell Line: N/D Experimental Design: blood Case Sample: blood from ovarian cancer Control Sample: normal blood Num of Case: 15 Num of Control: 70 Quantification Software: limma Num of miRNAs: 863 |
| Identification | Num of Up: 1 Num of Down: 6 |