| Experiment ID | EXP00328 |
| Reference | Title: Treatment-independent miRNA signature in blood of Wilms tumor patients. Author: Schmitt J, Backes C, Nourkami-Tutdibi N, Leidinger P, Deutscher S, Beier M,Gessler M, Graf N, Lenhof HP, Keller A, Meese E. Journal: BMC Genomics. 2012 Aug 7;13:379. doi: 10.1186/1471-2164-13-379. Abstract: BACKGROUND: Blood-born miRNA signatures have recently been reported for varioustumor diseases. Here, we compared the miRNA signature in Wilms tumor patientsprior and after preoperative chemotherapy according to SIOP protocol 2001.RESULTS: We did not find a significant difference between miRNA signature of bothgroups. However both, Wilms tumor patients prior and after chemotherapy showed a miRNA signature different from healthy controls. The signature of Wilms tumorpatients prior to chemotherapy showed an accuracy of 97.5% and of patients after chemotherapy an accuracy of 97.0%, each as compared to healthy controls.CONCLUSION: Our results provide evidence for a blood-born Wilms tumor miRNAsignature largely independent of four weeks preoperative chemotherapy treatment. PMID: 22871070 |
| Expressiion Profile | Description: miRNA profiles of Wilms tumor patients and controls Organism: Homo sapiens GEO ID: GSE38419 Platform: GPL9040 Number of samples: 42 |
| Design and Sample | Cancer Type: kidney cancer Cancer SubType: wilms tumor Cell Line: N/D Experimental Design: blood Case Sample: blood from kidney cancer Control Sample: normal blood Num of Case: 23 Num of Control: 19 Quantification Software: limma Num of miRNAs: 848 |
| Identification | Num of Up: 153 Num of Down: 155 |